Golder V, Hoi A (2017) Systemic lupus erythematosus: an update. Our findings need to be validated by further investigations using larger, better-designed RCTs. ConclusionsĪlfacalcidol and calcitriol were the most efficacious treatment arms for increasing lumbar spine and femoral neck BMD, respectively. None of the treatment arms ruled out the possibility of no effect for any outcome. Cholecalciferol+calcium ranked first in terms of its ability to increase total hip BMD however this finding needs to be interpreted with caution due to low sample sizes in the cholecalciferol+calcium treatment arm. We found alfacalcidol+calcium to yield the greatest percentage increase in lumbar spine BMD (MD 6.05, 95% credible interval − 4.18 to 16.18) compared to no treatment, and calcitriol+calcium to yield the greatest percentage increase in femoral neck BMD (MD 8.46, 95% CrI − 4.74 to 21.51) compared to no treatment. We included 16 RCTs containing 1073 eligible patients in our analysis. Outcomes were percentage change in lumbar spine, femoral neck, and total hip BMD from baseline.
A database search of MEDLINE, EMBASE, Web of Science, CINAHL, CENTRAL and Chinese databases were conducted for relevant randomized controlled trials (RCTs). We performed NMAs based on a prospectively developed protocol.
The objective of our systematic review and network meta-analysis (NMA) is to investigate which vitamin D and/or calcium regimen would yield the greatest increase in lumbar spine, femoral neck, and total hip bone mineral density (BMD) in adult patients undergoing glucocorticoid therapy.
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